Sptlc3 | serine palmitoyltransferase, long chain base subunit 3
Physiological systems
20 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Nervous system Vision/eye
17 No significant impact
4 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal optic disk morphology | 1 supporting dataset | Sptlc3em1(IMPC)Hmgu | homozygote | Early adult | 2.8x10-5 | ||
| cataract | 1 supporting dataset | Sptlc3em1(IMPC)Hmgu | homozygote | Early adult | 2.74x10-7 | ||
| increased circulating calcium level | 1 supporting dataset | Sptlc3em1(IMPC)Hmgu | homozygote | Early adult | 6.68x10-5 | ||
| abnormal lens morphology | 1 supporting dataset | Sptlc3em1(IMPC)Hmgu | homozygote | Early adult | 1.77x10-7 |
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Human diseases caused by Sptlc3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Sptlc3.
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| Sptlc3em1(IMPC)Hmgu | Exon Deletion | | mouse |
| Sptlc3tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |