Mapkap1 | mitogen-activated protein kinase associated protein 1
Physiological systems
22 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Embryo Growth/size/body region Vision/eye Mortality/aging Cardiovascular system
17 No significant impact
2 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
62Embryo tissues
| decreased total retina thickness | 1 supporting dataset | Mapkap1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 3.12x10-5 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Mapkap1tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Mapkap1tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Mapkap1tm1b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * | ||
| increased cornea thickness | 1 supporting dataset | Mapkap1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 1.57x10-5 | ||
| abnormal embryo size | 1 supporting dataset | Mapkap1tm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| dilated heart left ventricle | 2 supporting datasets | Mapkap1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.62x10-5 |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Mapkap1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mapkap1.
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| Mapkap1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Mapkap1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Mapkap1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |