Atg4d | autophagy related 4D, cysteine peptidase

GeneMGI:2444308Synonyms: APG4-D, Apg4d, +2 more

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Vision/eye Behavior/neurological Cardiovascular system

15 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased thigmotaxis2 supporting datasetsAtg4dem1(IMPC)MarchomozygoteEarly adult8.36x10-5 
abnormal retina morphology1 supporting datasetAtg4dem1(IMPC)MarchomozygoteEarly adult2.47x10-6 
dilated heart left ventricle1 supporting datasetAtg4dem1(IMPC)MarchomozygoteEarly adult1.51x10-5 
abnormal behavior1 supporting datasetAtg4dem1(IMPC)MarchomozygoteEarly adult8.36x10-5 
increased anxiety-related response1 supporting datasetAtg4dem1(IMPC)MarchomozygoteEarly adult4.4x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Atg4dem1(IMPC)MarcDeletionmouse
Atg4dtm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Atg4dtm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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