Setx | senataxin
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Vision/eye Hematopoietic system
14 No significant impact
4 Not tested
Data collections
Gene metrics:10Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased monocyte cell number | 1 supporting dataset | Setxtm1b(EUCOMM)Wtsi | homozygote | Early adult | 7.84x10-10 | ||
| decreased lymphocyte cell number | 2 supporting datasets | Setxtm1b(EUCOMM)Wtsi | homozygote | Early adult | 6.23x10-6 | ||
| male infertility | 1 supporting dataset | Setxtm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased leukocyte cell number | 1 supporting dataset | Setxtm1b(EUCOMM)Wtsi | homozygote | Early adult | 9.29x10-5 | ||
| increased neutrophil cell number | 1 supporting dataset | Setxtm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.49x10-6 | ||
| small testis | 1 supporting dataset | Setxtm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased NK cell number | 2 supporting datasets | Setxtm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.36x10-5 | ||
| improved glucose tolerance | 1 supporting dataset | Setxtm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.85x10-5 | ||
| increased eosinophil cell number | 1 supporting dataset | Setxtm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.09x10-7 | ||
| decreased total retina thickness | 1 supporting dataset | Setxtm1b(EUCOMM)Wtsi | homozygote | Early adult | 9.68x10-5 |
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Human diseases caused by Setx mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Setx.
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| Setxtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Setxtm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |