Setx | senataxin

GeneMGI:2443480Synonyms: A930037J23Rik, Als4

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Vision/eye Hematopoietic system

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased monocyte cell number	1 supporting dataset	Setx^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.84x10^-10
decreased lymphocyte cell number	2 supporting datasets	Setx^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.23x10^-6
male infertility	1 supporting dataset	Setx^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased leukocyte cell number	1 supporting dataset	Setx^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.29x10^-5
increased neutrophil cell number	1 supporting dataset	Setx^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.49x10^-6
small testis	1 supporting dataset	Setx^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased NK cell number	2 supporting datasets	Setx^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.36x10^-5
improved glucose tolerance	1 supporting dataset	Setx^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.85x10^-5
increased eosinophil cell number	1 supporting dataset	Setx^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.09x10^-7
decreased total retina thickness	1 supporting dataset	Setx^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.68x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Setx.

Associated images

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Histopathology

There is no histopathology data found for Setx.

IMPC related publications

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External links

No external links available for Setx.

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*Setx^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Setx^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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