Fndc9 | fibronectin type III domain containing 9
Physiological systems
17 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton
9 No significant impact
7 Not tested
Data collections
Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased mean platelet volume | 1 supporting dataset | Fndc9tm1.1(KOMP)Vlcg | homozygote | Early adult | 9.55x10-6 | ||
| increased total body fat amount | 2 supporting datasets | Fndc9tm1.1(KOMP)Vlcg | homozygote | Early adult | 3.29x10-10 | ||
| female infertility | 1 supporting dataset | Fndc9tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| decreased thigmotaxis | 1 supporting dataset | Fndc9tm1.1(KOMP)Vlcg | homozygote | Early adult | 9.63x10-5 | ||
| decreased lean body mass | 2 supporting datasets | Fndc9tm1.1(KOMP)Vlcg | homozygote | Early adult | 5.08x10-8 | ||
| decreased bone mineral content | 1 supporting dataset | Fndc9tm1.1(KOMP)Vlcg | homozygote | Early adult | 4.58x10-5 | ||
| hyperactivity | 6 supporting datasets | Fndc9tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.75x10-20 | ||
| decreased grip strength | 2 supporting datasets | Fndc9tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.21x10-6 | ||
| increased circulating bilirubin level | 1 supporting dataset | Fndc9tm1.1(KOMP)Vlcg | homozygote | Early adult | 4.04x10-9 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Fndc9tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.89x10-9 |
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Human diseases caused by Fndc9 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Fndc9.
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| Fndc9tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Fndc9tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Fndc9tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Fndc9tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |