Tmc7 | transmembrane channel-like gene family 7
Physiological systems
20 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Vision/eye Liver/biliary system Hematopoietic system
11 No significant impact
4 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal eye morphology | 1 supporting dataset | Tmc7em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal liver morphology | 1 supporting dataset | Tmc7em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| increased circulating cholesterol level | 1 supporting dataset | Tmc7em1(IMPC)Mbp | homozygote | Late adult | 1.15x10-5 | ||
| abnormal skin morphology | 1 supporting dataset | Tmc7em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| female infertility | 1 supporting dataset | Tmc7em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal eye morphology | 1 supporting dataset | Tmc7em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Tmc7em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| enlarged spleen | 1 supporting dataset | Tmc7em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| microphthalmia | 1 supporting dataset | Tmc7em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| abnormal ovary morphology | 1 supporting dataset | Tmc7em1(IMPC)Mbp | homozygote | Late adult | N/A * |
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Human diseases caused by Tmc7 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Tmc7.
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| Tmc7em1(IMPC)Mbp | Exon Deletion | | mouse |
| Tmc7tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Tmc7tm380245(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |