Ttll1 | tubulin tyrosine ligase-like 1
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging
14 No significant impact
4 Not tested
Data collections
Viability data
Body weight measurements
Embryo imaging data
Body weight measurements
Embryo imaging data
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Ttll1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 1.72x10-5 | ||
| decreased hemoglobin content | 1 supporting dataset | Ttll1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 6.7x10-5 | ||
| increased lean body mass | 2 supporting datasets | Ttll1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 3.76x10-6 | ||
| abnormal tail movements | 1 supporting dataset | Ttll1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 4.57x10-5 | ||
| increased IgE level | 1 supporting dataset | Ttll1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 2.14x10-5 | ||
| increased total body fat amount | 1 supporting dataset | Ttll1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 1.37x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Ttll1tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased startle reflex | 1 supporting dataset | Ttll1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 8.53x10-5 |
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Human diseases caused by Ttll1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ttll1.
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| Ttll1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ttll1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |