Taf2 | TATA-box binding protein associated factor 2
Physiological systems
18 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Limbs/digits/tail Behavior/neurological Skeleton Mortality/aging
13 No significant impact
6 Not tested
Data collections
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| hyperactivity | 1 supporting dataset | Taf2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 7.1x10-7 | ||
| increased circulating cholesterol level | 1 supporting dataset | Taf2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.32x10-5 | ||
| decreased grip strength | 1 supporting dataset | Taf2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 4.81x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Taf2tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal cholesterol homeostasis | 1 supporting dataset | Taf2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 9.5x10-5 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Taf2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.49x10-6 | ||
| long tibia | 1 supporting dataset | Taf2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.47x10-5 |
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Human diseases caused by Taf2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Taf2.
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| Taf2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Taf2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Taf2tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Taf2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Taf2tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Taf2tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |