Ogfod1 | 2-oxoglutarate and iron-dependent oxygenase domain containing 1
Physiological systems
20 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Integument Adipose tissue Growth/size/body region Hematopoietic system
16 No significant impact
4 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased lean body mass | 1 supporting dataset | Ogfod1tm1a(KOMP)Wtsi | homozygote | Early adult | 8.13x10-5 | ||
| abnormal skin condition | 1 supporting dataset | Ogfod1tm1a(KOMP)Wtsi | homozygote | Early adult | 1.53x10-5 | ||
| decreased total body fat amount | 1 supporting dataset | Ogfod1tm1a(KOMP)Wtsi | homozygote | Early adult | 2.85x10-5 | ||
| decreased hemoglobin content | 1 supporting dataset | Ogfod1tm1a(KOMP)Wtsi | homozygote | Early adult | 6.46x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Ogfod1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ogfod1.
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| Ogfod1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ogfod1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Ogfod1tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ogfod1tm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Ogfod1tm42340(L1L2_Pgk_PM) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |