Ints6l | integrator complex subunit 6 like

GeneMGI:2442593Synonyms: 4930535D10Rik, 6330505F04Rik, +1 more

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Muscle Hematopoietic system Behavior/neurological Cardiovascular system

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased heart left ventricle size	1 supporting dataset	Ints6l^{em1(IMPC)Marc}	homozygote	Early adult	8.58x10^-6
decreased cardiac muscle contractility	2 supporting datasets	Ints6l^{em1(IMPC)Marc}	hemizygote	Early adult	3.97x10^-7
decreased red blood cell distribution width	1 supporting dataset	Ints6l^{em1(IMPC)Marc}	hemizygote	Early adult	1.33x10^-5
increased circulating triglyceride level	1 supporting dataset	Ints6l^{em1(IMPC)Marc}	hemizygote	Early adult	9.65x10^-5
thin ventricular wall	2 supporting datasets	Ints6l^{em1(IMPC)Marc}	hemizygote	Early adult	1.9x10^-8
dilated heart left ventricle	2 supporting datasets	Ints6l^{em1(IMPC)Marc}	hemizygote	Early adult	7.56x10^-9
decreased heart left ventricle size	2 supporting datasets	Ints6l^{em1(IMPC)Marc}	hemizygote	Early adult	4.42x10^-8
decreased circulating phosphate level	1 supporting dataset	Ints6l^{em1(IMPC)Marc}	homozygote	Early adult	6.8x10^-6
decreased circulating phosphate level	1 supporting dataset	Ints6l^{em1(IMPC)Marc}	hemizygote	Early adult	7.09x10^-5
increased circulating triglyceride level	1 supporting dataset	Ints6l^{em1(IMPC)Marc}	homozygote	Early adult	5.31x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ints6l.

Associated images

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Histopathology

There is no histopathology data found for Ints6l.

IMPC related publications

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External links

No external links available for Ints6l.

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*Ints6l^{em1(IMPC)Marc}*	Indel	‌	mouse
*Ints6l^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ints6l^{tm352029(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Ints6l^{tm3e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Ints6l^{tm41150(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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