Ubxn2a | UBX domain protein 2A
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Mortality/aging
15 No significant impact
5 Not tested
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| embryonic growth retardation | 1 supporting dataset | Ubxn2atm1b(EUCOMM)Hmgu | heterozygote | E9.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Ubxn2atm1b(EUCOMM)Hmgu | heterozygote | E9.5 | N/A * | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Ubxn2atm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| edema | 1 supporting dataset | Ubxn2atm1b(EUCOMM)Hmgu | homozygote | E15.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Ubxn2atm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Ubxn2atm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 50% (1/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | Section images | 50% (1/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 50% (1/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Ubxn2a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ubxn2a.
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| Ubxn2atm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Ubxn2atm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ubxn2atm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ubxn2atm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Ubxn2atm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ubxn2atm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |