Mfn2 | mitofusin 2
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Growth/size/body region Behavior/neurological Mortality/aging
16 No significant impact
5 Not tested
Data collections
Gene metrics:3Significant phenotypes
9Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal gait | 1 supporting dataset | Mfn2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.96x10-5 | ||
| decreased lean body mass | 1 supporting dataset | Mfn2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.17x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Mfn2tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
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Human diseases caused by Mfn2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mfn2.
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| Mfn2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Mfn2tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |