Hs3st5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5

GeneMGI:2441996Synonyms: LOC382362, D930005L05Rik

Physiological systems

20 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Vision/eye Renal/urinary system

18 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

small kidney1 supporting datasetHs3st5em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal kidney morphology1 supporting datasetHs3st5em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal eye morphology1 supporting datasetHs3st5em1(IMPC)MbphomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Human diseases caused by Hs3st5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Hs3st5em1(IMPC)MbpExon Deletionmouse
Hs3st5tm1a(KOMP)MbpKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Hs3st5tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Hs3st5tm1e(KOMP)MbpTargeted, non-conditional alleleES Cell
Hs3st5tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Hs3st5tm2a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Hs3st5tm2e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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