Tbc1d4 | TBC1 domain family, member 4
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Hematopoietic system
15 No significant impact
6 Not tested
Data collections
Gene metrics:5Significant phenotypes
1Associated diseases
Expression examined in:49Adult tissues
25Embryo tissues
| decreased leukocyte cell number | 1 supporting dataset | Tbc1d4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.99x10-5 | ||
| decreased circulating chloride level | 1 supporting dataset | Tbc1d4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.78x10-6 | ||
| increased hematocrit | 1 supporting dataset | Tbc1d4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.86x10-5 | ||
| increased mean corpuscular volume | 1 supporting dataset | Tbc1d4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.69x10-5 | ||
| increased circulating sodium level | 1 supporting dataset | Tbc1d4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.11x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/1) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Tbc1d4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tbc1d4.
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| Tbc1d4tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tbc1d4tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Tbc1d4tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |