Acsf2 | acyl-CoA synthetase family member 2
GeneMGI:2388287
Physiological systems
17 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Hematopoietic system Behavior/neurological
15 No significant impact
7 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
47Embryo tissues
| abnormal sleep behavior | 1 supporting dataset | Acsf2tm1.1(KOMP)Vlcg | homozygote | Early adult | 7.58x10-5 | ||
| hyperactivity | 2 supporting datasets | Acsf2tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.1x10-5 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Acsf2tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.2x10-8 | ||
| increased mean corpuscular volume | 1 supporting dataset | Acsf2tm1.1(KOMP)Vlcg | homozygote | Early adult | 6.65x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Acsf2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Acsf2.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Acsf2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Acsf2tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Acsf2tm91937(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |