Ano2 | anoctamin 2
Physiological systems
22 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Immune system Endocrine/exocrine gland Hematopoietic system Behavior/neurological
18 No significant impact
2 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| hyperactivity | 7 supporting datasets | Ano2em1(IMPC)Ccpcz | homozygote | Early adult | 4.42x10-7 | ||
| enlarged thymus | 1 supporting dataset | Ano2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal thymus morphology | 1 supporting dataset | Ano2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal behavior | 1 supporting dataset | Ano2em1(IMPC)Ccpcz | homozygote | Early adult | 9.68x10-6 | ||
| decreased thigmotaxis | 2 supporting datasets | Ano2em1(IMPC)Ccpcz | homozygote | Early adult | 9.68x10-6 | ||
| decreased anxiety-related response | 1 supporting dataset | Ano2em1(IMPC)Ccpcz | homozygote | Early adult | 7.84x10-8 | ||
| enlarged lymph nodes | 1 supporting dataset | Ano2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal lymph node morphology | 1 supporting dataset | Ano2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * |
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Human diseases caused by Ano2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ano2.
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| Ano2em1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Ano2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ano2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |