Ddx27 | DEAD box helicase 27

GeneMGI:2385884Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 27

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Immune system Hematopoietic system Behavior/neurological Mortality/aging

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, incomplete penetrance	1 supporting dataset	Ddx27^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Ddx27^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased granulocyte number	1 supporting dataset	Ddx27^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	1.74x10^-5
abnormal behavior	3 supporting datasets	Ddx27^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	6.36x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression



adrenal gland	heterozygote	n/a	100% (2/2)	0.7% (4/570)
aorta	heterozygote	n/a	n/a	0.19% (1/533)
blood vessel	heterozygote	n/a	0% (0/2)	0% (0/173)
bone	heterozygote	n/a	n/a	0% (0/394)
brain	heterozygote	n/a	100% (2/2)	0.86% (5/579)
brainstem	heterozygote	n/a	n/a	0.41% (2/490)
brown adipose tissue	heterozygote	n/a	0% (0/2)	0% (0/588)
cartilage tissue	heterozygote	n/a	100% (1/1)	0.22% (1/454)
cerebellum	heterozygote	n/a	n/a	0.56% (3/532)
cerebral cortex	heterozygote	n/a	n/a	0.41% (2/491)

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Associated images

There are no images available for Ddx27.

Human diseases caused by Ddx27 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.



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Histopathology

There is no histopathology data found for Ddx27.

IMPC related publications

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External links

No external links available for Ddx27.

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*Ddx27^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ddx27^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

My Genes

Ddx27 | DEAD box helicase 27

Physiological systems

4 Significantly impacted by the knock-out

16 No significant impact

4 Not tested

Data collections

Phenotypes

lacZ Expression

Associated images

Human diseases caused by Ddx27 mutations

Histopathology

IMPC related publications

External links

Order Mouse and ES Cells

The IMPC Newsletter

Access Data Release 22.1 Data