Gtpbp10 | GTP-binding protein 10 (putative)

GeneMGI:2385599Synonyms: 4930545J22Rik

Physiological systems

17 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Integument Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

10 No significant impact

7 Not tested

Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues

Phenotypes

increased grip strength1 supporting datasetGtpbp10tm1b(KOMP)MbphomozygoteLate adult3.95x10-5 
abnormal vibrissa morphology1 supporting datasetGtpbp10tm1b(KOMP)MbphomozygoteLate adult8.3x10-7 
increased heart rate1 supporting datasetGtpbp10tm1b(KOMP)MbphomozygoteLate adult6.62x10-5 
increased hemoglobin content1 supporting datasetGtpbp10tm1b(KOMP)MbphomozygoteEarly adult8.38x10-6 
increased circulating creatinine level1 supporting datasetGtpbp10tm1b(KOMP)MbphomozygoteLate adult1.25x10-5 
increased mean corpuscular hemoglobin concentration1 supporting datasetGtpbp10tm1b(KOMP)MbphomozygoteEarly adult2.03x10-7 
abnormal lens morphology1 supporting datasetGtpbp10tm1b(KOMP)MbphomozygoteLate adult4.12x10-8 
abnormal cornea morphology1 supporting datasetGtpbp10tm1b(KOMP)MbphomozygoteLate adult2.77x10-5 
increased bone mineral content1 supporting datasetGtpbp10tm1b(KOMP)MbphomozygoteLate adult6.44x10-5 
decreased mean corpuscular volume1 supporting datasetGtpbp10tm1b(KOMP)MbphomozygoteEarly adult4.17x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoteSection images
100% (2/2)0.19% (1/533)
brainheterozygoten/a0% (0/2)0.86% (5/579)
brainstemheterozygoten/a0% (0/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cerebellumheterozygoten/a0% (0/2)0.56% (3/532)
cerebral cortexheterozygoten/a0% (0/2)0.41% (2/491)
epididymisheterozygoteSection images
100% (1/1)87.5% (21/24)
esophagusheterozygoteSection images
100% (2/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Gtpbp10tm1a(KOMP)MbpKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Gtpbp10tm1b(KOMP)MbpReporter-tagged deletion allele (with selection cassette)mouse
Gtpbp10tm1e(KOMP)MbpTargeted, non-conditional alleleES Cell

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