Tm4sf4 | transmembrane 4 superfamily member 4
Physiological systems
21 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Vision/eye Behavior/neurological Skeleton
18 No significant impact
3 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| abnormal bone structure | 1 supporting dataset | Tm4sf4tm1.1(KOMP)Vlcg | homozygote | Early adult | 4.95x10-5 | ||
| abnormal vocalization | 1 supporting dataset | Tm4sf4tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.02x10-5 | ||
| anophthalmia | 1 supporting dataset | Tm4sf4tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased bone mineral density | 1 supporting dataset | Tm4sf4tm1.1(KOMP)Vlcg | homozygote | Early adult | 4.67x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images Wholemount images | 50% (2/4) | 0.7% (4/570) |
| aorta | heterozygote | Wholemount images | 66.67% (2/3) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | Wholemount images | 100% (4/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 50% (2/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 100% (2/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images Wholemount images | 75% (3/4) | 0.56% (3/532) |
Human diseases caused by Tm4sf4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tm4sf4.
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| Tm4sf4tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Tm4sf4tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Tm4sf4tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |