Smc5 | structural maintenance of chromosomes 5

GeneMGI:2385088Synonyms: Smc5l1

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Behavior/neurological Mortality/aging

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

22Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased circulating bilirubin level	1 supporting dataset	Smc5^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.83x10^-6
increased neutrophil cell number	2 supporting datasets	Smc5^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.71x10^-10
tremors	1 supporting dataset	Smc5^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Smc5^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
thrombocytopenia	1 supporting dataset	Smc5^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.16x10^-5
decreased circulating cholesterol level	1 supporting dataset	Smc5^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.09x10^-6
decreased circulating HDL cholesterol level	1 supporting dataset	Smc5^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.67x10^-7
increased eosinophil cell number	1 supporting dataset	Smc5^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.29x10^-6
decreased lymphocyte cell number	1 supporting dataset	Smc5^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	6.07x10^-10
decreased circulating glucose level	1 supporting dataset	Smc5^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.31x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Smc5.

Associated images

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Histopathology

There is no histopathology data found for Smc5.

IMPC related publications

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External links

No external links available for Smc5.

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*Smc5^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Smc5^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Smc5^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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