Wrap53 | WD repeat containing, antisense to Trp53
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Cardiovascular system Mortality/aging
14 No significant impact
6 Not tested
Data collections
Gene metrics:8Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased circulating LDL cholesterol level | 1 supporting dataset | Wrap53tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6.77x10-5 | ||
| decreased circulating cholesterol level | 1 supporting dataset | Wrap53tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.58x10-6 | ||
| increased lean body mass | 1 supporting dataset | Wrap53tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.91x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Wrap53tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased circulating fructosamine level | 1 supporting dataset | Wrap53tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.59x10-5 | ||
| decreased circulating HDL cholesterol level | 1 supporting dataset | Wrap53tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.95x10-5 | ||
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Wrap53tm1b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * | ||
| increased heart weight | 1 supporting dataset | Wrap53tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.98x10-5 |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Wrap53 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Wrap53.
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| Wrap53tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Wrap53tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Wrap53tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |