Prpsap2 | phosphoribosyl pyrophosphate synthetase-associated protein 2
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton
14 No significant impact
4 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased startle reflex | 2 supporting datasets | Prpsap2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.03x10-9 | ||
| decreased CD8-positive, alpha-beta T cell number | 1 supporting dataset | Prpsap2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.23x10-5 | ||
| abnormal metabolism | 1 supporting dataset | Prpsap2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.66x10-5 | ||
| abnormal behavior | 1 supporting dataset | Prpsap2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.34x10-5 | ||
| short tibia | 1 supporting dataset | Prpsap2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 7.26x10-8 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Prpsap2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Prpsap2.
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| Prpsap2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Prpsap2tm297(pL1L2_GT2_DelLacZ_bsd) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Prpsap2tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |