Ndrg4 | N-myc downstream regulated gene 4
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Muscle Behavior/neurological Cardiovascular system
15 No significant impact
5 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| hyperactivity | 8 supporting datasets | Ndrg4tm1b(KOMP)Wtsi | homozygote | Early adult | 1.2x10-18 | ||
| decreased cardiac muscle contractility | 1 supporting dataset | Ndrg4tm1b(KOMP)Wtsi | homozygote | Early adult | 4.36x10-5 | ||
| increased blood urea nitrogen level | 1 supporting dataset | Ndrg4tm1b(KOMP)Wtsi | homozygote | Early adult | 6.87x10-8 | ||
| limb grasping | 1 supporting dataset | Ndrg4tm1b(KOMP)Wtsi | homozygote | Early adult | 9.41x10-7 | ||
| increased circulating creatinine level | 1 supporting dataset | Ndrg4tm1b(KOMP)Wtsi | homozygote | Early adult | 1.53x10-6 | ||
| abnormal gait | 1 supporting dataset | Ndrg4tm1b(KOMP)Wtsi | homozygote | Early adult | 6.29x10-10 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 50% (1/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Ndrg4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ndrg4.
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| Ndrg4tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ndrg4tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ndrg4tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |