Zfp280d | zinc finger protein 280D
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Muscle Nervous system Hematopoietic system Behavior/neurological Cardiovascular system
13 No significant impact
5 Not tested
Data collections
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased startle reflex | 1 supporting dataset | Zfp280dem1(IMPC)Hmgu | homozygote | Early adult | 1.08x10-16 | ||
| decreased locomotor activity | 2 supporting datasets | Zfp280dem1(IMPC)Hmgu | homozygote | Early adult | 3.31x10-5 | ||
| dilated heart left ventricle | 2 supporting datasets | Zfp280dem1(IMPC)Hmgu | homozygote | Early adult | 5.54x10-24 | ||
| decreased prepulse inhibition | 4 supporting datasets | Zfp280dem1(IMPC)Hmgu | homozygote | Early adult | 1.02x10-9 | ||
| prolonged QRS complex duration | 1 supporting dataset | Zfp280dem1(IMPC)Hmgu | homozygote | Early adult | 1.66x10-5 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Zfp280dem1(IMPC)Hmgu | homozygote | Early adult | 3.7x10-5 | ||
| decreased cardiac muscle contractility | 2 supporting datasets | Zfp280dem1(IMPC)Hmgu | homozygote | Early adult | 4.28x10-34 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Zfp280dem1(IMPC)Hmgu | homozygote | Early adult | 7.26x10-6 | ||
| decreased mean corpuscular hemoglobin concentration | 1 supporting dataset | Zfp280dem1(IMPC)Hmgu | homozygote | Early adult | 3.14x10-5 | ||
| abnormal startle reflex | 1 supporting dataset | Zfp280dem1(IMPC)Hmgu | homozygote | Early adult | 8.06x10-14 |
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Human diseases caused by Zfp280d mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Zfp280d.
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| Zfp280dem1(IMPC)Hmgu | Exon Deletion | | mouse |
| Zfp280dtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Zfp280dtm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |