Vps37d | vacuolar protein sorting 37D
Physiological systems
22 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Growth/size/body region Nervous system Vision/eye Behavior/neurological Mortality/aging
17 No significant impact
2 Not tested
Gene metrics:7Significant phenotypes
1Associated diseases
Expression examined in:49Adult tissues
62Embryo tissues
| unresponsive to tactile stimuli | 1 supporting dataset | Vps37dtm2b(EUCOMM)Wtsi | heterozygote | E18.5 | N/A * | ||
| decreased prepulse inhibition | 2 supporting datasets | Vps37dtm2b(EUCOMM)Wtsi | heterozygote | Early adult | 4.85x10-13 | ||
| decreased total retina thickness | 2 supporting datasets | Vps37dtm2b(EUCOMM)Wtsi | heterozygote | Early adult | 2.57x10-20 | ||
| unresponsive to tactile stimuli | 1 supporting dataset | Vps37dtm2b(EUCOMM)Wtsi | homozygote | E18.5 | N/A * | ||
| decreased locomotor activity | 2 supporting datasets | Vps37dtm2b(EUCOMM)Wtsi | heterozygote | Early adult | 1.71x10-5 | ||
| abnormal retina inner nuclear layer morphology | 2 supporting datasets | Vps37dtm2b(EUCOMM)Wtsi | heterozygote | Early adult | 5.11x10-20 | ||
| abnormal body wall morphology | 1 supporting dataset | Vps37dtm2b(EUCOMM)Wtsi | homozygote | E18.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Vps37dtm2b(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Wholemount images | 100% (2/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Vps37d mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Vps37d.
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| Vps37dtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Vps37dtm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Vps37dtm2b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Vps37dtm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |