Tmie | transmembrane inner ear
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Pigmentation Integument Behavior/neurological Mortality/aging
15 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal vocalization | 1 supporting dataset | Tmieem1(IMPC)J | heterozygote | Early adult | 2.42x10-10 | ||
| abnormal coat/hair pigmentation | 1 supporting dataset | Tmieem1(IMPC)J | heterozygote | Early adult | 4.2x10-12 | ||
| abnormal behavior | 1 supporting dataset | Tmieem1(IMPC)J | homozygote | Early adult | 5.63x10-7 | ||
| abnormal startle reflex | 1 supporting dataset | Tmieem1(IMPC)J | homozygote | Early adult | 1.58x10-5 | ||
| increased aggression | 1 supporting dataset | Tmieem1(IMPC)J | homozygote | Early adult | 5.12x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Tmieem1(IMPC)J | homozygote | Early adult | N/A * | ||
| head bobbing | 1 supporting dataset | Tmieem1(IMPC)J | homozygote | Early adult | 5.63x10-7 |
| | | | | | | | | | |
Human diseases caused by Tmie mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tmie.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Tmieem1(IMPC)J | Exon Deletion | | mouse |
| Tmietm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Tmietm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Tmietm429560(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Tmietm429560(L1L2_GT0_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |