Cln6 | ceroid-lipofuscinosis, neuronal 6
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Adipose tissue Growth/size/body region Nervous system Vision/eye Cardiovascular system
12 No significant impact
7 Not tested
Data collections
Gene metrics:4Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased prepulse inhibition | 2 supporting datasets | Cln6tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.36x10-7 | ||
| abnormal retina morphology | 1 supporting dataset | Cln6tm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.86x10-13 | ||
| increased heart weight | 1 supporting dataset | Cln6tm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.57x10-5 | ||
| decreased total body fat amount | 1 supporting dataset | Cln6tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.97x10-5 |
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Human diseases caused by Cln6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Cln6.
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| Cln6tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Cln6tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cln6tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Cln6tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Cln6tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |