Gsk3a | glycogen synthase kinase 3 alpha
Physiological systems
22 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system Craniofacial
15 No significant impact
2 Not tested
Data collections
Gene metrics:14Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| abnormal gait | 1 supporting dataset | Gsk3atm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.74x10-7 | ||
| abnormal gait | 1 supporting dataset | Gsk3atm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.86x10-12 | ||
| decreased body weight | 1 supporting dataset | Gsk3anot yet available | homozygote | Early adult | 2.57x10-7 | ||
| decreased body weight | 4 supporting datasets | Gsk3atm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.76x10-6 | ||
| decreased circulating glucose level | 1 supporting dataset | Gsk3atm1a(EUCOMM)Wtsi | homozygote | Early adult | 9.21x10-5 | ||
| improved glucose tolerance | 1 supporting dataset | Gsk3atm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.18x10-5 | ||
| increased total body fat amount | 1 supporting dataset | Gsk3anot yet available | homozygote | Early adult | 9.33x10-5 | ||
| decreased exploration in new environment | 1 supporting dataset | Gsk3atm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.05x10-6 | ||
| prolonged QRS complex duration | 1 supporting dataset | Gsk3atm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.93x10-5 | ||
| decreased mean platelet volume | 1 supporting dataset | Gsk3atm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.96x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (1/1) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (1/1) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
External links
No external links available for Gsk3a.
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| Gsk3atm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Gsk3atm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Gsk3atm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Gsk3atm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Gsk3atm40413(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |