Necab2 | N-terminal EF-hand calcium binding protein 2
Physiological systems
19 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Homeostasis/metabolism
18 No significant impact
5 Not tested
Data collections
Gene metrics:1Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased circulating serum albumin level | 1 supporting dataset | Necab2tm1a(KOMP)Wtsi | homozygote | Early adult | 2.21x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Necab2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Necab2.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Necab2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Necab2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Necab2tm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Necab2tm42356(L1L2_Pgk_PM) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Necab2tm42356(L1L2_gt2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |