Slc13a3 | solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Physiological systems
21 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Respiratory system Hematopoietic system
17 No significant impact
3 Not tested
Data collections
Gene metrics:5Significant phenotypes
1Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| increased circulating creatinine level | 1 supporting dataset | Slc13a3tm1b(KOMP)Wtsi | homozygote | Early adult | 1.58x10-13 | ||
| increased neutrophil cell number | 1 supporting dataset | Slc13a3tm1b(KOMP)Wtsi | homozygote | Early adult | 1.18x10-6 | ||
| increased monocyte cell number | 1 supporting dataset | Slc13a3tm1b(KOMP)Wtsi | homozygote | Early adult | 1.52x10-5 | ||
| increased pulmonary ventilation | 1 supporting dataset | Slc13a3tm1b(KOMP)Wtsi | homozygote | Early adult | 4.25x10-5 | ||
| decreased lymphocyte cell number | 1 supporting dataset | Slc13a3tm1b(KOMP)Wtsi | homozygote | Early adult | 2.09x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/4) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | Wholemount images | 100% (4/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 50% (2/4) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images Wholemount images | 100% (4/4) | 0.56% (3/532) |
Human diseases caused by Slc13a3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Slc13a3.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Slc13a3tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Slc13a3tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Slc13a3tm355928(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |