Slc5a5 | solute carrier family 5 (sodium iodide symporter), member 5

GeneMGI:2149330Synonyms: NIS

Physiological systems

18 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Hearing/vestibular/ear Vision/eye Nervous system Behavior/neurological Skeleton Renal/urinary system

10 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

2Associated diseases

Expression examined in:48Adult tissues

50Embryo tissues

Phenotypes

Phy. System:

Life Stage:



hyperactivity	8 supporting datasets	Slc5a5^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.08x10^-27
abnormal coat appearance	3 supporting datasets	Slc5a5^{tm1b(KOMP)Wtsi}	homozygote	Late adult	4.74x10^-7
abnormal auditory brainstem response	4 supporting datasets	Slc5a5^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.44x10^-8
increased grip strength	1 supporting dataset	Slc5a5^{tm1b(KOMP)Wtsi}	homozygote	Late adult	1.31x10^-5
cornea deposits	1 supporting dataset	Slc5a5^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.19x10^-5
increased exploration in new environment	1 supporting dataset	Slc5a5^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.45x10^-7
decreased exploration in new environment	1 supporting dataset	Slc5a5^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.36x10^-6
decreased bone mineral density	1 supporting dataset	Slc5a5^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.87x10^-7
decreased urine creatinine level	1 supporting dataset	Slc5a5^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.78x10^-7
increased circulating cholesterol level	1 supporting dataset	Slc5a5^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.29x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Slc5a5.

Associated images

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Histopathology

There is no histopathology data found for Slc5a5.

IMPC related publications

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External links

No external links available for Slc5a5.

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*Slc5a5^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Slc5a5^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Slc5a5^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Slc5a5^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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