Kiss1r | KISS1 receptor
Physiological systems
21 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Renal/urinary system
10 No significant impact
3 Not tested
Data collections
Gene metrics:28Significant phenotypes
5Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| decreased locomotor activity | 4 supporting datasets | Kiss1rtm1.1(KOMP)Vlcg | homozygote | Early adult | 1.56x10-6 | ||
| increased thymus weight | 1 supporting dataset | Kiss1rtm1.1(KOMP)Vlcg | homozygote | Early adult | 8.78x10-5 | ||
| abnormal kidney morphology | 1 supporting dataset | Kiss1rtm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| absent ovary | 1 supporting dataset | Kiss1rtm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| decreased bone mineral content | 2 supporting datasets | Kiss1rtm1.1(KOMP)Vlcg | homozygote | Early adult | 5.89x10-25 | ||
| small kidney | 1 supporting dataset | Kiss1rtm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| abnormal uterus morphology | 1 supporting dataset | Kiss1rtm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| abnormal epididymis morphology | 1 supporting dataset | Kiss1rtm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| absent testes | 1 supporting dataset | Kiss1rtm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| absent epididymis | 1 supporting dataset | Kiss1rtm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Kiss1r mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Kiss1r.
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