Cldn16 | claudin 16

GeneMGI:2148742Synonyms: paracellin-1, PCLN1, +1 more

Physiological systems

19 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Skeleton

17 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

2Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating calcium level	1 supporting dataset	Cldn16^{tm1a(KOMP)Wtsi}	homozygote	Early adult	9.88x10^-12
decreased bone mineral content	1 supporting dataset	Cldn16^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.03x10^-5
increased circulating amylase level	1 supporting dataset	Cldn16^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.25x10^-6
increased circulating creatinine level	1 supporting dataset	Cldn16^{tm1a(KOMP)Wtsi}	homozygote	Early adult	4.41x10^-12

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cldn16.

Associated images

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Histopathology

There is no histopathology data found for Cldn16.

IMPC related publications

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External links

No external links available for Cldn16.

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*Cldn16^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Cldn16^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Cldn16^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell
*Cldn16^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Cldn16^{tm46517(L1L2_hubi_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes