Atg4a | autophagy related 4A, cysteine peptidase
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Adipose tissue Growth/size/body region Hematopoietic system Skeleton
12 No significant impact
7 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased total body fat amount | 2 supporting datasets | Atg4aem2(IMPC)Marc | homozygote | Early adult | 3.23x10-8 | ||
| increased basophil cell number | 2 supporting datasets | Atg4aem2(IMPC)Marc | homozygote | Early adult | 1.11x10-22 | ||
| decreased bone mineral content | 2 supporting datasets | Atg4aem2(IMPC)Marc | homozygote | Early adult | 1.8x10-8 | ||
| increased eosinophil cell number | 2 supporting datasets | Atg4aem2(IMPC)Marc | homozygote | Early adult | 1.97x10-15 | ||
| decreased lean body mass | 1 supporting dataset | Atg4aem2(IMPC)Marc | homozygote | Early adult | 2.84x10-7 | ||
| decreased bone mineral density | 1 supporting dataset | Atg4aem2(IMPC)Marc | homozygote | Early adult | 6.12x10-5 |
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Human diseases caused by Atg4a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Atg4a.
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| Atg4aem2(IMPC)Marc | Deletion | | mouse |