Tmem132a | transmembrane protein 132A
Physiological systems
22 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Adipose tissue Embryo Growth/size/body region Limbs/digits/tail Nervous system Behavior/neurological Skeleton Craniofacial Mortality/aging
13 No significant impact
2 Not tested
Gene metrics:16Significant phenotypes
0Associated diseases
Expression examined in:51Adult tissues
62Embryo tissues
| abnormal limb morphology | 1 supporting dataset | Tmem132atm1b(KOMP)Wtsi | homozygote | E15.5 | N/A * | ||
| increased total body fat amount | 1 supporting dataset | Tmem132atm1b(KOMP)Wtsi | heterozygote | Early adult | 2.7x10-5 | ||
| abnormal limb morphology | 1 supporting dataset | Tmem132atm1b(KOMP)Wtsi | homozygote | E18.5 | N/A * | ||
| syndactyly | 1 supporting dataset | Tmem132atm1b(KOMP)Wtsi | homozygote | E15.5 | N/A * | ||
| abnormal head shape | 1 supporting dataset | Tmem132atm1b(KOMP)Wtsi | homozygote | E18.5 | N/A * | ||
| abnormal tail morphology | 2 supporting datasets | Tmem132atm1b(KOMP)Wtsi | homozygote | E18.5 | N/A * | ||
| abnormal tail morphology | 1 supporting dataset | Tmem132atm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| unresponsive to tactile stimuli | 1 supporting dataset | Tmem132atm1b(KOMP)Wtsi | heterozygote | E18.5 | N/A * | ||
| abnormal facial morphology | 1 supporting dataset | Tmem132atm1b(KOMP)Wtsi | homozygote | E18.5 | N/A * | ||
| abnormal cranium morphology | 1 supporting dataset | Tmem132atm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Tmem132a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tmem132a.
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| Tmem132atm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tmem132atm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Tmem132atm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Tmem132atm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Tmem132atm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |