Otub1 | OTU domain, ubiquitin aldehyde binding 1
GeneMGI:2147616
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Vision/eye Respiratory system Behavior/neurological Skeleton Mortality/aging Cardiovascular system Craniofacial
13 No significant impact
4 Not tested
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
44Embryo tissues
| decreased exploration in new environment | 1 supporting dataset | Otub1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.95x10-14 | ||
| decreased grip strength | 2 supporting datasets | Otub1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.2x10-6 | ||
| preweaning lethality, complete penetrance | 2 supporting datasets | Otub1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| decreased bone mineral content | 1 supporting dataset | Otub1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.73x10-6 | ||
| abnormal heart position or orientation | 2 supporting datasets | Otub1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
| abnormal lung morphology | 1 supporting dataset | Otub1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
| abnormal cranium morphology | 1 supporting dataset | Otub1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 7.86x10-5 | ||
| increased cornea thickness | 1 supporting dataset | Otub1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 9.89x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Otub1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Otub1.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Otub1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Otub1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Otub1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Otub1tm83433(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |