Otub1 | OTU domain, ubiquitin aldehyde binding 1

GeneMGI:2147616

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Vision/eye Respiratory system Behavior/neurological Skeleton Mortality/aging Cardiovascular system Craniofacial

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

44Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased exploration in new environment	1 supporting dataset	Otub1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.95x10^-14
decreased grip strength	2 supporting datasets	Otub1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.2x10^-6
preweaning lethality, complete penetrance	2 supporting datasets	Otub1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased bone mineral content	1 supporting dataset	Otub1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.73x10^-6
abnormal heart position or orientation	2 supporting datasets	Otub1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
abnormal lung morphology	1 supporting dataset	Otub1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
abnormal cranium morphology	1 supporting dataset	Otub1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.86x10^-5
increased cornea thickness	1 supporting dataset	Otub1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.89x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Otub1.

Associated images

Loading...

Histopathology

There is no histopathology data found for Otub1.

IMPC related publications

Loading...

External links

No external links available for Otub1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Otub1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Otub1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Otub1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Otub1^{tm83433(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes