AU021092 | expressed sequence AU021092

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Behavior/neurological Cardiovascular system Renal/urinary system

16 No significant impact

3 Not tested

Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

enlarged heart1 supporting datasetAU021092tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
decreased circulating glucose level1 supporting datasetAU021092tm1b(KOMP)WtsihomozygoteEarly adult1.05x10-5 
hyperactivity2 supporting datasetsAU021092tm1b(KOMP)WtsiheterozygoteEarly adult9.76x10-5 
increased heart weight2 supporting datasetsAU021092tm1b(KOMP)WtsihomozygoteEarly adult1.81x10-15 
abnormal kidney morphology1 supporting datasetAU021092tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
abnormal heart morphology1 supporting datasetAU021092tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
abnormal urinary bladder morphology1 supporting datasetAU021092tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
decreased circulating calcium level1 supporting datasetAU021092tm1b(KOMP)WtsiheterozygoteEarly adult1.69x10-5 
abnormal heart morphology1 supporting datasetAU021092tm1b(KOMP)WtsiheterozygoteEarly adultN/A * 
enlarged heart1 supporting datasetAU021092tm1b(KOMP)WtsiheterozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/4)0.7% (4/570)
aortaheterozygoten/a0% (0/4)0.19% (1/533)
bloodheterozygoten/a0% (0/2)0% (0/17)
bone marrowheterozygoten/a0% (0/2)0% (0/22)
brainheterozygoten/a0% (0/4)0.86% (5/579)
brainstemheterozygoten/a0% (0/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cecumheterozygoten/a0% (0/1)7.75% (22/284)
cerebellumheterozygoten/a0% (0/4)0.56% (3/532)
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Histopathology

IMPC related publications

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AU021092tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
AU021092tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
AU021092tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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