Scrib | scribbled planar cell polarity
Physiological systems
19 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Nervous system Vision/eye Behavior/neurological Mortality/aging Cardiovascular system Craniofacial
10 No significant impact
5 Not tested
Gene metrics:14Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
50Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Scribtm1b(NCOM)Mfgc | homozygote | Early adult | N/A * | ||
| abnormal craniofacial morphology | 1 supporting dataset | Scribtm1b(NCOM)Mfgc | homozygote | E15.5 | N/A * | ||
| abnormal craniofacial morphology | 1 supporting dataset | Scribtm1b(NCOM)Mfgc | homozygote | E12.5 | N/A * | ||
| abnormal retina morphology | 1 supporting dataset | Scribtm1b(NCOM)Mfgc | heterozygote | Early adult | 5.66x10-7 | ||
| abnormal neural tube closure | 1 supporting dataset | Scribtm1b(NCOM)Mfgc | homozygote | E9.5 | N/A * | ||
| abnormal midbrain morphology | 1 supporting dataset | Scribtm1b(NCOM)Mfgc | homozygote | E12.5 | N/A * | ||
| abnormal gait | 1 supporting dataset | Scribtm1b(NCOM)Mfgc | heterozygote | Early adult | 8.3x10-5 | ||
| abnormal hindbrain morphology | 1 supporting dataset | Scribtm1b(NCOM)Mfgc | homozygote | E12.5 | N/A * | ||
| pale yolk sac | 1 supporting dataset | Scribtm1b(NCOM)Mfgc | homozygote | E12.5 | N/A * | ||
| abnormal eye morphology | 1 supporting dataset | Scribtm1b(NCOM)Mfgc | homozygote | E12.5 | N/A * |
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Human diseases caused by Scrib mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Scrib.
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| Scribtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Scribtm1a(NCOM)Mfgc | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Scribtm1b(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | mouse |