Trib2 | tribbles pseudokinase 2

GeneMGI:2145021Synonyms: TRB2

Physiological systems

21 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Vision/eye Behavior/neurological Mortality/aging

18 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:50Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal retina outer nuclear layer morphology	1 supporting dataset	Trib2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.68x10^-8
hyperactivity	2 supporting datasets	Trib2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.63x10^-5
decreased total retina thickness	2 supporting datasets	Trib2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.22x10^-16
abnormal retina inner nuclear layer morphology	2 supporting datasets	Trib2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	0
abnormal retina inner nuclear layer morphology	2 supporting datasets	Trib2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.08x10^-9
decreased total retina thickness	2 supporting datasets	Trib2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	6.25x10^-9
preweaning lethality, incomplete penetrance	3 supporting datasets	Trib2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Trib2.

Associated images

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Histopathology

There is no histopathology data found for Trib2.

IMPC related publications

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External links

No external links available for Trib2.

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*Trib2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Trib2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Trib2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Trib2^{tm45705(pL1L2_frt_BetactP_neo_frt_lox)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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