Smg6 | SMG6 nonsense mediated mRNA decay factor
Physiological systems
22 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Immune system Integument Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging
16 No significant impact
2 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged spleen | 1 supporting dataset | Smg6em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Smg6em1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| scaly skin | 1 supporting dataset | Smg6em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Smg6em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 2 supporting datasets | Smg6em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Smg6em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal startle reflex | 1 supporting dataset | Smg6em1(IMPC)Mbp | heterozygote | Middle aged adult | 1.94x10-5 |
| | | | | | | | | | |
Human diseases caused by Smg6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Smg6.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Smg6em1(IMPC)Mbp | Exon Deletion | | mouse |
| Smg6tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Smg6tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |