Cyp4v3 | cytochrome P450, family 4, subfamily v, polypeptide 3
GeneMGI:2142763
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Growth/size/body region Vision/eye Liver/biliary system Behavior/neurological Mortality/aging
15 No significant impact
4 Not tested
Data collections
Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal liver morphology | 1 supporting dataset | Cyp4v3em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| hyperactivity | 1 supporting dataset | Cyp4v3em1(IMPC)Mbp | homozygote | Early adult | 5.19x10-8 | ||
| abnormal liver morphology | 1 supporting dataset | Cyp4v3em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal eye morphology | 1 supporting dataset | Cyp4v3em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Cyp4v3em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| enlarged liver | 1 supporting dataset | Cyp4v3em1(IMPC)Mbp | homozygote | Late adult | N/A * |
| | | | | | | | | | |
Human diseases caused by Cyp4v3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Cyp4v3.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Cyp4v3em1(IMPC)Mbp | Exon Deletion | | mouse |
| Cyp4v3tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Cyp4v3tm44867(L1L2_st0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |