Cyp4v3 | cytochrome P450, family 4, subfamily v, polypeptide 3

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Growth/size/body region Vision/eye Liver/biliary system Behavior/neurological Mortality/aging

15 No significant impact

4 Not tested

Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal liver morphology1 supporting datasetCyp4v3em1(IMPC)MbphomozygoteLate adultN/A * 
hyperactivity1 supporting datasetCyp4v3em1(IMPC)MbphomozygoteEarly adult5.19x10-8 
abnormal liver morphology1 supporting datasetCyp4v3em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal eye morphology1 supporting datasetCyp4v3em1(IMPC)MbphomozygoteEarly adultN/A * 
preweaning lethality, incomplete penetrance3 supporting datasetsCyp4v3em1(IMPC)MbphomozygoteEarly adultN/A * 
enlarged liver1 supporting datasetCyp4v3em1(IMPC)MbphomozygoteLate adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cyp4v3em1(IMPC)MbpExon Deletionmouse
Cyp4v3tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Cyp4v3tm44867(L1L2_st0)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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