Lrrk1 | leucine-rich repeat kinase 1

GeneMGI:2142227Synonyms: D130026O16Rik, C230002E15Rik

Physiological systems

20 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Craniofacial

10 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:39Significant phenotypes

2Associated diseases

Expression examined in:46Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal femur morphology	1 supporting dataset	Lrrk1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.51x10^-14
decreased lean body mass	1 supporting dataset	Lrrk1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	8.11x10^-5
abnormal eyelid morphology	1 supporting dataset	Lrrk1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.19x10^-31
abnormal ulna morphology	1 supporting dataset	Lrrk1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.43x10^-7
abnormal tooth morphology	3 supporting datasets	Lrrk1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.03x10^-15
thrombocytopenia	1 supporting dataset	Lrrk1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.69x10^-17
increased red blood cell distribution width	1 supporting dataset	Lrrk1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.19x10^-15
abnormal radius morphology	1 supporting dataset	Lrrk1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.43x10^-8
increased circulating aspartate transaminase level	1 supporting dataset	Lrrk1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.8x10^-13
abnormal zygomatic bone morphology	1 supporting dataset	Lrrk1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.44x10^-12

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lrrk1.

Associated images

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Histopathology

There is no histopathology data found for Lrrk1.

IMPC related publications

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External links

No external links available for Lrrk1.

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*Lrrk1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Lrrk1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Lrrk1^{tm1c(KOMP)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Lrrk1^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Lrrk1^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Lrrk1^{tm43355(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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