Ube3c | ubiquitin protein ligase E3C
GeneMGI:2140998
Physiological systems
20 / 24 physiological systems tested
12 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Muscle Nervous system Vision/eye Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton Cardiovascular system
8 No significant impact
4 Not tested
Data collections
Gene metrics:29Significant phenotypes
1Associated diseases
Expression examined in:152Adult tissues
25Embryo tissues
| increased cardiac muscle contractility | 2 supporting datasets | Ube3ctm1b(EUCOMM)Hmgu | homozygote | Late adult | 2.68x10-6 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Ube3ctm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.99x10-5 | ||
| decreased prepulse inhibition | 3 supporting datasets | Ube3ctm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.29x10-7 | ||
| increased circulating alkaline phosphatase level | 2 supporting datasets | Ube3ctm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.96x10-9 | ||
| increased total body fat amount | 1 supporting dataset | Ube3ctm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.86x10-5 | ||
| increased effector memory CD8-positive, alpha-beta T cell number | 1 supporting dataset | Ube3ctm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.44x10-5 | ||
| decreased Ly6C-positive NK T cell number | 1 supporting dataset | Ube3ctm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.45x10-6 | ||
| decreased body length | 2 supporting datasets | Ube3ctm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.94x10-6 | ||
| decreased exploration in new environment | 2 supporting datasets | Ube3ctm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.22x10-8 | ||
| decreased locomotor activity | 2 supporting datasets | Ube3ctm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.18x10-5 |
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| adrenal gland | heterozygote | Wholemount images | 100% (4/4) | 0.7% (4/570) |
| adrenal gland | homozygote | Wholemount images | 100% (2/2) | 0.7% (4/570) |
| aorta | homozygote | Wholemount images | 100% (2/2) | 0.19% (1/533) |
| aorta | heterozygote | Wholemount images | 100% (4/4) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | n/a | 0% (0/394) |
| bone | homozygote | Wholemount images | n/a | 0% (0/394) |
| brain | homozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brain | heterozygote | Wholemount images | 100% (4/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (4/4) | 0.41% (2/490) |
| brainstem | homozygote | n/a | 100% (2/2) | 0.41% (2/490) |
Human diseases caused by Ube3c mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ube3c.
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| Ube3ctm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ube3ctm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ube3ctm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |