Lrrc8c | leucine rich repeat containing 8 family, member C
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Vision/eye Hematopoietic system Mortality/aging
13 No significant impact
4 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased circulating calcium level | 1 supporting dataset | Lrrc8cem1(IMPC)Mbp | homozygote | Early adult | 3.55x10-6 | ||
| abnormal eye morphology | 1 supporting dataset | Lrrc8cem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Lrrc8cem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal testis morphology | 1 supporting dataset | Lrrc8cem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| small testis | 1 supporting dataset | Lrrc8cem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| decreased circulating serum albumin level | 1 supporting dataset | Lrrc8cem1(IMPC)Mbp | homozygote | Early adult | 9.78x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Lrrc8cem1(IMPC)Mbp | homozygote | Early adult | N/A * |
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Human diseases caused by Lrrc8c mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Lrrc8c.
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| Lrrc8cem1(IMPC)Mbp | Exon Deletion | | mouse |