Wdr47 | WD repeat domain 47
Physiological systems
21 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Integument Growth/size/body region Hematopoietic system Behavior/neurological
15 No significant impact
3 Not tested
Data collections
Gene metrics:14Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased grip strength | 2 supporting datasets | Wdr47tm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.01x10-8 | ||
| limb grasping | 1 supporting dataset | Wdr47tm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.43x10-7 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Wdr47tm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.65x10-5 | ||
| abnormal skin pigmentation | 1 supporting dataset | Wdr47tm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.33x10-5 | ||
| decreased circulating LDL cholesterol level | 1 supporting dataset | Wdr47tm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.31x10-5 | ||
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Wdr47tm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.16x10-6 | ||
| decreased body weight | 1 supporting dataset | Wdr47tm1a(EUCOMM)Wtsi | homozygote | Early adult | 6.33x10-10 | ||
| hyperactivity | 1 supporting dataset | Wdr47tm1a(EUCOMM)Wtsi | homozygote | Early adult | 6x10-6 | ||
| decreased hemoglobin content | 1 supporting dataset | Wdr47tm1a(EUCOMM)Wtsi | homozygote | Early adult | 6.96x10-5 | ||
| abnormal skin morphology | 1 supporting dataset | Wdr47tm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.96x10-5 |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Wdr47 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Wdr47.
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| Wdr47tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Wdr47tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Wdr47tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |