Pkmyt1 | protein kinase, membrane associated tyrosine/threonine 1

GeneMGI:2137630Synonyms: Myt1

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Integument Embryo Nervous system Liver/biliary system Behavior/neurological Mortality/aging

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased grip strength1 supporting datasetPkmyt1em1(IMPC)JheterozygoteEarly adult1.95x10-6 
prenatal lethality prior to heart atrial septation1 supporting datasetPkmyt1em1(IMPC)JhomozygoteE15.5N/A * 
pallor1 supporting datasetPkmyt1em1(IMPC)JhomozygoteE12.5N/A * 
abnormal neural tube closure1 supporting datasetPkmyt1em1(IMPC)JhomozygoteE12.5N/A * 
abnormal forebrain morphology1 supporting datasetPkmyt1em1(IMPC)JhomozygoteE12.5N/A * 
abnormal vocalization1 supporting datasetPkmyt1em1(IMPC)JheterozygoteEarly adult2.42x10-10 
preweaning lethality, complete penetrance1 supporting datasetPkmyt1em1(IMPC)JhomozygoteEarly adultN/A * 
pale liver1 supporting datasetPkmyt1em1(IMPC)JhomozygoteE12.5N/A * 
abnormal coat/ hair morphology1 supporting datasetPkmyt1em1(IMPC)JheterozygoteEarly adult2.71x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Pkmyt1em1(IMPC)JExon Deletionmouse
Pkmyt1tm267248(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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