Baiap2 | brain-specific angiogenesis inhibitor 1-associated protein 2
Physiological systems
22 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Hematopoietic system Mortality/aging
17 No significant impact
2 Not tested
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
51Embryo tissues
| abnormal testis morphology | 1 supporting dataset | Baiap2tm1b(KOMP)Wtsi | heterozygote | Early adult | N/A * | ||
| thrombocytopenia | 1 supporting dataset | Baiap2tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.42x10-5 | ||
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Baiap2tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| edema | 1 supporting dataset | Baiap2tm1b(KOMP)Wtsi | homozygote | E15.5 | N/A * | ||
| decreased circulating calcium level | 1 supporting dataset | Baiap2tm1b(KOMP)Wtsi | heterozygote | Early adult | 2.23x10-6 | ||
| small testis | 1 supporting dataset | Baiap2tm1b(KOMP)Wtsi | heterozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 50% (1/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Baiap2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Baiap2.
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| Baiap2tm119226(L1L2_Pgk_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Baiap2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Baiap2tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Baiap2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |