Mrpl3 | mitochondrial ribosomal protein L3
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Mortality/aging
15 No significant impact
6 Not tested
Data collections
Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Mrpl3em1(IMPC)J | heterozygote | Early adult | 7.78x10-5 | ||
| increased circulating bilirubin level | 1 supporting dataset | Mrpl3em1(IMPC)J | heterozygote | Early adult | 5.72x10-5 | ||
| increased hemoglobin content | 1 supporting dataset | Mrpl3em1(IMPC)J | heterozygote | Early adult | 8.25x10-5 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Mrpl3em1(IMPC)J | homozygote | E9.5 | N/A * | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Mrpl3em1(IMPC)J | heterozygote | Early adult | 3.8x10-18 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Mrpl3em1(IMPC)J | homozygote | Early adult | N/A * |
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Human diseases caused by Mrpl3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mrpl3.
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| Mrpl3em1(IMPC)J | Exon Deletion | | mouse |
| Mrpl3tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Mrpl3tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Mrpl3tm3e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Mrpl3tm4a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Mrpl3tm4e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |