Sirt1 | sirtuin 1
Physiological systems
20 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Immune system Growth/size/body region Vision/eye Hematopoietic system Skeleton Craniofacial Cardiovascular system Mortality/aging
12 No significant impact
4 Not tested
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| increased basophil cell number | 2 supporting datasets | Sirt1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6.63x10-12 | ||
| abnormal scapula morphology | 1 supporting dataset | Sirt1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.33x10-5 | ||
| abnormal sinus arrhythmia | 1 supporting dataset | Sirt1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 8.74x10-9 | ||
| abnormal tooth morphology | 1 supporting dataset | Sirt1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.29x10-6 | ||
| abnormal iris morphology | 1 supporting dataset | Sirt1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.89x10-6 | ||
| abnormal snout morphology | 1 supporting dataset | Sirt1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.9x10-5 | ||
| abnormal pelvic girdle bone morphology | 1 supporting dataset | Sirt1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 8.03x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Sirt1tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal maxilla morphology | 1 supporting dataset | Sirt1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.08x10-5 | ||
| narrow eye opening | 1 supporting dataset | Sirt1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.87x10-7 |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Sirt1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Sirt1.
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| Sirt1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Sirt1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Sirt1tm1c(EUCOMM)Wtsi | Wild type floxed exon (post-Flp) | | mouse |
| Sirt1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |