Klf7 | Kruppel-like transcription factor 7 (ubiquitous)
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Hematopoietic system Behavior/neurological Skeleton Mortality/aging
14 No significant impact
4 Not tested
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| hyperactivity | 8 supporting datasets | Klf7tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.45x10-19 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Klf7tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.78x10-11 | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Klf7tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.72x10-5 | ||
| abnormal vertebrae morphology | 1 supporting dataset | Klf7tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.26x10-5 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Klf7tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 4.76x10-6 | ||
| increased mean platelet volume | 1 supporting dataset | Klf7tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.47x10-9 | ||
| impaired righting response | 1 supporting dataset | Klf7tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 4.63x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Klf7tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
External links
No external links available for Klf7.
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| Klf7tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Klf7tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Klf7tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |